The technology proposed by Carmetry is based on artificial intelligence and geolocation, and it consists of the use of a model of three-dimensional variables to analyse, within a spatial and temporal range, the GPS trajectory of an individual who is COVID-19 positive. This algorithm Will make it possible, via a mobile device, to determin which people an infected individual came in contact with during the virus incubation period. At each point of the trajectory of the coronavirus-infected individual, the algorithm considers, in addition to the proximity between both individuals, the length of time of exposure to the virus to estimate the viral load of the infection within a radius, beginning with the initial trajectory and throughout the remaining GPS trajectories.
“The important thing is to crosscheck anonymous data from hundreds of thousands of people, then apply an intelligent algorithm that manages to help the country,” said Arturo Gil and David Úbeda, the founders of Carmetry. As such, this UMH Scientific Park start-up makes the intelligence of its clusters available to the public in order to warn people who have been in contact with infected individuals early on, regardless of whether they know each other or not, and also if their paths simply crossed while buying bread. The technology that makes it posible to track the contagion will be used during the specific period of the pandemic, and then erased, thus maintaining a commitment to data treatment confidentiality. Furthermore, Carmetry’s algorithm has dissociated all personal and medical data, for whose storage hosting such data is not even necessary.
https://www.alphagal...y/ItemId/193046 The announcements pleased politicians trying to offer hope to citizens desperate to leave lockdowns and investors eager for economic activity to return.
But many scientists feel a duty to damp the enthusiasm. They say a vaccine could take much longer because little is known about the disease and how bodies will react to attempts at immunization. In fact, some warn we may never create a vaccine for Covid-19.
Soumya Swaminathan, chief scientist for the World Health Organization, believes an optimistic scenario is a vaccine produced in the “tens of millions” next year, which would be mainly distributed to healthcare workers, and far larger volumes in 2022. To inoculate the world and defeat Covid-19 could take four to five years, she says.
We have no “crystal ball” to tell the future, she told the Financial Times. “It depends how the virus behaves: whether it mutates, whether it becomes more or less virulent, more or less transmittable.”
Peter Hotez, a professor at the Baylor College of Medicine in Houston who is developing a vaccine, says the US president sees vaccines as a “manufacturing problem,” like making enough ventilators or tests.
“Manufacturing is not the hurdle. It’s taking the time to collect enough efficacy and safety data,” he says. “The Operation Warp Speed language coming out of the White House and biotechs and pharma companies [saying] that they will have a vaccine by the fall—or in weeks or days—does so much damage.”
Vaccines are usually developed over many years and even decades. A 2013 paper from Dutch scientists says the average vaccine took 10.71 years and had only a 6 per cent success rate from start to finish. Each stage is an experiment: from the small phase one trials happening now to the large phase three trials needed for regulatory approval.
longish
https://arstechnica....ccine-research/ Researchers at the University of Exeter Medical School and the University of Connecticut School of Medicine analysed data from the UK Biobank, and found high risk of severe COVID-19 infection among European ancestry participants who carry two faulty copies of the APOE gene (termed e4e4). One in 36 people of European ancestry have two faulty copies of this gene, and this is known to increase risks of Alzheimer's disease up to 14-fold* and also increases risks of heart disease.
Now, the research team has found that carrying these gene mutations doubles the risks of COVID-19 - even in people who had not developed these diseases.
The team has previously found that people with dementia are three times more likely to get severe COVID-19, yet they are not one of the groups advertised to shield - or shelter in place - on health grounds. Part of the increased risk effect may have been exposure to the high prevalence of the virus in care homes. However, the new study, published in the Journal of Gerontology: Medical Sciences, indicates that a genetic component may also be at play. The team found that people with the APOE e4e4 genotype were at double the risk of developing severe COVID-19, compared to those with the common e3e3 form of the APOE gene. The team used data from the UK Biobank study, which collects health and genetic data on 500,000 people.
https://www.eurekale...e-dgr052220.phpPeer-reviewed data shows remdesivir for COVID-19 improves time to recovery
https://www.eurekale...a-pds052220.php Since April 1, a team of immunologists, medical scientists, and virologists, has been collecting blood samples from volunteers who have recovered from COVID-19. The majority of the samples they have studied showed poor to modest "neutralizing activity," indicating a weak antibody response. However, a closer look revealed everyone's immune system is capable of generating effective antibodies—just not necessarily enough of them. Even when neutralizing antibodies were not present in an individual's serum in large quantities, researchers could find some rare immune cells that make them.
"This suggests just about everybody can do this, which is very good news for vaccines," says Michel C. Nussenzweig, head of the Laboratory of Molecular Immunology at Rockefeller. "It means if you were able to create a vaccine that elicits these particular antibodies, then the vaccine is likely to be effective and work for a lot of people."
Moreover, the researchers identified three distinct antibodies that were shown to be the most potent of the bunch in neutralizing the virus. They are working to develop them further into therapeutic and preventive drugs.
https://medicalxpres...ogy-reveal.html Rheumatologists at the University of Alberta are flagging similarities between the deaths of some COVID-19 patients and those with rheumatic illnesses, and are testing proven rheumatic treatments to see whether they help against the pandemic virus.
A substantial proportion of COVID-19 patients admitted to intensive care die of pneumonia due to a cytokine storm, where the body attacks itself rather than fighting off the illness, said Jan Willem Cohen Tervaert, director of rheumatology in the Department of Medicine.
In a new paper published in Autoimmunity Reviews, Cohen Tervaert and his colleagues note that such storms, whether in patients with COVID-19 or rheumatic diseases, are caused by dysfunctional "natural killer" (NK) immune cells.
They say that SARS-CoV-2, the virus that causes COVID-19, might attack NK cells directly by binding to angiotensin converting enzyme 2 (ACE-2), a receptor on the cells that COVID-19 researchers believe attracts and opens the door to the virus.
https://medicalxpres...ths-severe.html The World Health Organization said Monday it had "temporarily" suspended clinical trials of hydroxychloriquine as a potential treatment for COVID-19 being carried out across a range of countries as a precautionary measure.
The decision came after the publication last week of a study in the Lancet indicating that using the drug on COVID-19 patients could increase their likelihood of dying, WHO chief Tedros Adhanom Ghebreyesus told a virtual press conference.
https://english.alar...id-19-treatment Using the system, Dr. Kamran Khan, a University of Toronto researcher and member of the Infectious Disease Division of St. Michael’s Hospital, and his team of 50 researchers were alerted to the coronavirus outbreak in Wuhan, China on New Year’s Eve.
The computer program algorithm picked up a blog post that told of a 20-person pneumonia outbreak in Wuhan. It took only seconds for the program to analyze airline schedules and pick 20 places that were in the path of the virus. As it turned out, 12 of those places were the first to report the presence and outbreak of COVID-19.
Virus appearing in Bangkok sets off alarm
When the virus was detected in Bangkok, Thailand on Jan. 13, Khan said it set off alarm bells.
“If you see a case show up outside of Wuhan in another country, it’s telling you that the outbreak is much bigger than a couple dozen cases,” he told the Canadian Press. “That’s the moment we were quite concerned.”
The software combs through hundreds of thousands of news reports in 65 languages every day, seeking to uncover information on disease trouble spots. BlueDot’s speed is of the essence as the world has been slow to react to possible pandemics.
https://www.aa.com.t...-system/1853536China conducts over 6.5 million COVID-19 tests in Wuhan
https://www.aa.com.t...n-wuhan/1853473MOSCOW, May 26. /TASS/. British Prime Minister Boris Johnson has officially invited Russian President Vladimir Putin to take part in a virtual summit devoted to research into a vaccine against the novel coronavirus, the British embassy in Moscow said on Telegram.
"On June 4, the British government will hold the Global Vaccine Summit 2020. British Prime Minister Boris Johnson has officially invited Russian President Vladimir Putin to participate in the virtual summit," the embassy said.
The main task of the summit is to mobilize resources the Global Alliance for Vaccines and Immunization will need to ensure universal availability of the vaccine against the novel coronavirus.
https://tass.com/world/1160547And since the United States is a "highly litigious society," he added, these conflicts often end up in court.
A first wave of lawsuits has come from prisons and immigration centers, said Torston Kracht, a litigation partner with Hunton Andrews Kurth: prisoners have demanded to be paroled early, arguing that sanitary conditions in their facilities are poor and in some cases are aggravating detainees' existing health problems.
Some prisoners, including former Donald Trump campaign director Paul Manafort and former Trump attorney Michael Cohen, have won early release.
Others have found themselves caught up in epic legal battles: the US government has just asked the Supreme Court to block the early release of 800 inmates from the Elkton Federal Correctional Institution in eastern Ohio.
*snip*
A second big category of lawsuits deals with efforts to seek compensation for financial losses.
Ticket buyers who saw events canceled have filed a class-action suit against the online reservation site Ticketmaster, while others are seeking compensation for lost hotel or airline reservations, or even for memberships in gyms that have been closed for months.
Since early May, demands from students seeking to recover tuition expenses and fees have surged. And business and shop owners, forced to remain closed, have sued various governmental entities to challenge confinement orders.
http://www.globaltim...t/1189320.shtmlMulvaney: 'We've overreacted a little bit' to coronavirus
https://thehill.com/...-to-coronavirus‘I don’t even listen to him anymore’: Older Florida voters revolt over Trump’s COVID-19 response
https://www.rawstory...id-19-response/Britain’s finance minister, Rishi Sunak, has authorized a plan to save strategically important companies in exceptional circumstances, the Financial Times reported, citing details shared with the newspaper by the Treasury.
Under the plan called Project Birch, the government would rescue any companies whose failure would “disproportionately harm the economy,” the Financial Times said. A Treasury official declined to comment on the report.
While it’s not clear which companies the government deems strategically important, some of the nation’s biggest employers are reeling, the travel industry has collapsed and auto sales have all but folded. Last month, the Bank of England warned that the outlook for jobs was “horrendous.”
Among the bigger announcements detailing the corporate carnage, Rolls-Royce Holdings Plc is cutting 9,000 jobs, utility Ovo is axing 2,600 positions and Virgin Atlantic Airways Ltd. is trying to avert collapse. Jaguar Land Rover, the country’s largest automaker with some 38,000 employees, is in talks to borrow more than 1 billion pounds ($1.2 billion) through the emergency coronavirus lending program, people familiar with the matter said.
https://www.bloomber...nt-companies-ft
Edited by amor de cosmos, 26 May 2020 - 07:16 AM.