A new study has been published on the bioRxiv* preprint server, which has identified and characterized two RBD-targeting neutralizing nanobodies, namely, DL4 and DL28. These nanobodies were isolated from immunized alpaca, a South American camelid mammal. This study has revealed that RBM-antibodies tend to escape mutants and has discovered nanobodies that can be used to develop potent therapeutics against SARS-CoV-2 variants.
https://www.news-med...SARS-CoV-2.aspx
In a new study, published recently in the journal Circulation Research, scientists discover how the production of protective molecules known as specialised pro-resolving mediators (SPM) is altered in patients with COVID-19.
The results suggest that treatments which increase SPM production, such as dexamethasone or SPM based drugs, could play a key role in limiting inflammation in these patients.
Currently there is little understanding around the mechanisms that lead to uncontrolled inflammation in patients with COVID-19.
The study found a link between decreased SPM blood levels and disrupted white blood cell responses in patients with a higher disease burden. The findings also revealed that dexamethasone, the first drug approved for treatment of patients with COVID-19, increased the levels of these protective molecules in these patients. Furthermore, treatment of white blood cells with SPM improved their function and reduced the expression of molecules linked to the spread of inflammation. Understanding these mechanisms will help provide new leads into the development of treatments to limit disease severity in patients with COVID-19.
This study offers a new insight into the disrupted biological processes that contribute to increased disease severity in COVID-19 patients. Results suggest that treatments which increase SPM production, such as dexamethasone or SPM based drugs, could play a key role in limiting inflammation in this patient group.
https://www.eurekale...o-nii072221.php
Receiving the WHO’s blessing means the vaccine can now be used to supply Covax, the initiative set up to share vaccine doses across the world. This is on top of it being approved for use by 37 countries. Millions are in line to receive the vaccine, and millions already have.
However, CoronaVac’s clinical trial results have painted a mixed picture. And, as with the western COVID-19 vaccines, it’s only now that plenty of doses have been deployed that we’re beginning to get a sense of how effective the vaccine is in real-world conditions.
A traditional approach
Like the other notable Chinese COVID-19 vaccine, manufactured by Sinopharm, CoronaVac is an inactivated vaccine. This means it contains whole versions of the coronavirus that have been treated so that they can’t replicate inside the body. These dead viruses are what the body mounts an immune response to.
This is a very different approach to that used by the main western vaccines, which instead deliver some of the coronavirus’s genetic material into the body in order to get it to build specific, recognisable parts of the coronavirus for the immune system to train itself against.
The inactivated vaccine method is a much more well-established way of designing a vaccine. Inactivated vaccines are typically easy to manufacture at large scale and have an excellent safety record. However, they tend to produce a weaker immune response than vaccines that use other designs.
To some extent this is borne out in the results of CoronaVac’s phase 3 clinical trials, which were run across several countries. In a trial run in Brazil, the vaccine prevented people developing symptomatic COVID-19 with 51% efficacy. In another trial in Indonesia, the vaccine showed 65% efficacy. For comparison, the efficacy of the Moderna and Pfizer mRNA vaccines exceeded 90% in their trials.
However, CoronaVac showed very high protection against being hospitalised with COVID-19 in these trials, and almost 100% protection against dying from the disease, and it was on the basis of these findings that the WHO recommended its use. Since then, results of a further phase 3 trial run in Turkey have been published, suggesting that CoronaVac is safe and has an efficacy of 83%.
*snip*
Therefore, in the context of a pandemic that shows no signs of abating, what does the future hold for CoronaVac? Well, in short, the world needs all the vaccines it can get, and we cannot afford to pick and choose between them. There’s good evidence that all the vaccines approved by the WHO protect against symptomatic disease, and also evidence that they in turn reduce onward transmission.
While vaccine demand continues to greatly outstrip supply and there’s huge inequity in the global vaccine rollout, there remains a big role for CoronaVac to play – even if it is slightly less effective than some other vaccines. Populations remain unprotected. Until that changes, the pandemic won’t end.
https://theconversat...efulness-164577
People in low- and middle-income countries tend to be much more willing to receive a COVID-19 vaccine than are those in the United States, according to an analysis that included poll results from a dozen countries.
The analysis, reported on 16 July in Nature Medicine, found that 80% of individuals surveyed in ten low- and middle-income countries (LMICs) in Asia, Africa and South America were willing to receive a COVID-19 vaccine, compared with 65% in the United States. Upper-middle-income Russia is an outlier: only 30% of people there were willing to have the jab.
The study authors say the results suggest that ensuring equitable access to COVID-19 vaccines worldwide is not only a moral imperative, but also a powerful way to stem the spread of the virus: lower levels of hesitancy make widespread vaccination easier.
“Beyond the equity concerns, sharing vaccines is also the most efficient thing to do,” says Ahmed Mushfiq Mobarak, an economist at Yale University in New Haven, Connecticut, and a co-author of the study. “You want to give vaccines to people who are eager to take them.”
https://www.nature.c...586-021-01987-9
Nineteen new COVID-19 cases reported at Tokyo Olympics
Overall, 110 cases of the coronavirus have been reported so far at the Olympics in Tokyo
https://tass.com/sport/1316859
Eric Clapton refuses to play venues that "discriminate" by requiring COVID vaccine proof
"I will not perform on any stage where there is a discriminated audience present"
https://www.salon.co...-vaccine-proof/
Alabama Gov. Kay Ivey, who for much of the pandemic resisted public health measures, criticized her state's unvaccinated population in comments on Thursday.
Ivey, a Republican, once feuded with her own lieutenant governor over what he warned was a weak coronavirus response, told reporters on Thursday that she's "done all that I know how to do."
"I don't know, you tell me," she said when asked what it would take to get more people vaccinated. "Folks supposed to have common sense. But it's time to start blaming the unvaccinated folks, not the regular folks. It's the unvaccinated folks that are letting us down."
Alabama currently has the fourth lowest vaccination rate nationwide, according to The New York Times tracker.
https://www.business...ed-video-2021-7
(CNN) Sunny worked as a nurse on a Covid-19 floor of a hospital at the height of the pandemic. The work was hard, but what made it surreal was doing it while living in small town Arkansas, where many people, even some in her own family, said the virus was overblown -- "just the flu."
"It's extremely difficult to watch so many people die, and then have people tell you on Facebook or in Walmart that you're a liar," Sunny said. Sometimes that would come from the loved ones of the patients she was taking care of.
"We had people accuse us of giving their loved one something else so that they would die and we could report it as Covid. We heard it more than once that we were fudging the numbers, or we were killing people on purpose to make Covid look like it was worse than it was, or to make it look real when it wasn't," she said.
Sunny asked CNN not to use her real name, because some dedicated Covid-19 deniers have harassed health care workers, or tried to get outspoken ones fired.
*snip*
Sunny, the other Arkansas nurse, got on TikTok last year to vent and has used her account to spread awareness of what nurses were going through. She has since racked up nearly 140,000 followers with a mix of nurse-related comedy and searing stories about life on the Covid floor.
Other nurses sent her messages, thanking her for speaking out. But her videos were not always well received.
"I get called a crisis actor all the time," she said, referring to the conspiracy theory that victims of mass casualty events are actually actors paid by the government. "It's my thing now to respond to hate comments with, 'For just $10 into my Venmo account, I'll tell you the truth about Covid-19 and crisis acting.'"
So far she says she's made about $100. "I'm just like, 'Crisis acting isn't it real. And Covid is real. Surprise! I said I'd tell you the truth, not the truth you wanted to hear.'"
When Sunny meets Covid deniers in real life, she says she usually tears up and then awkwardly walks away. She even saw it within her own family.
"My own dad -- who I love, and is a great person -- I had to show him, like, no, this is real," she said. He was slowly convinced by "watching what it did to me personally -- getting phone calls from me during work where I'm just broken down crying ... There was so much death."
He got the vaccine.
https://www.cnn.com/...cine/index.html
The Fox News host Sean Hannity walked back his enthusiasm for COVID-19 vaccines after winning approval from President Joe Biden for praising vaccinations on his show earlier in the week.
Hannity told viewers on his show Thursday that he had "never told anyone to get a vaccine."
"I've been very clear," he said. "I am simply not qualified. I am not a medical doctor. I know nothing about your medical history or your current medical condition."
https://www.business...approves-2021-7
Rep. Madison Cawthorn (R-NC) said on Thursday that Dr. Anthony Fauci should be prosecuted for allegedly lying to Congress.
During a Senate hearing on Tuesday, Fauci was involved in an explosive exchange with Sen. Rand Paul (R-KY) about whether the National Institutes of Health (NIH) funded a grant for gain-of-function research at the Wuhan Institute of Virology, where the Covid-19 virus may have originated. Paul began his questioning by saying, “Dr. Fauci, as you are aware, it is a crime to lie to Congress.”
Fauci insisted the NIH had not funded gain-of-function research at the lab, which Paul vehemently disputed. Each man accused the other of lying, and Fauci emphatically told Paul, “You do not know what you’re talking about!”
Later that day, Paul said he would write to the Department of Justice (DOJ) seeking a criminal referral for Fauci for allegedly lying to Congress.
“His referral to the DOJ I think is well-founded,” said Cawthorn. “You can tell, he has directly lied to Congress.”
Cawthorn said Fauci’s hands were shaking during his back-and-forth with Paul not out of rage, but fear.
“Dr. Fauci knows he has been working as a pawn of the Chinese Communist Party,” said Cawthorn. He then baselessly alleged that the NIH has funded “militaristic research on how to make an animal virus more transmissible to humans.”
https://www.mediaite...ecute-this-guy/
is there any bigger loser in congress
Sen. Ted Cruz (R-Texas) is being haunted by a previous prediction he made about the future of the COVID-19 pandemic if President Joe Biden were to win the election. As Delta variant cases of COVID-19 continue to rise across the country at alarming rates, Cruz is being reminded of how he envisioned the pandemic ending if Democrats managed to win in November 2020.
Speaking to The Hill last July exactly one year ago, the Texas lawmaker claimed the pandemic might magically disappear if Democrats won the presidential election.
"If it ends up that Biden wins in November -- I hope he doesn't, I don't think he will -- but if he does, I guarantee you the week after the election, suddenly all those Democratic governors, all those Democratic mayors, will say, 'Everything's magically better. Go back to work. Go back to school. Suddenly all the problems are solved.' You won't to have to wait for Biden to be sworn in. All they'll need is Election Day and suddenly their willingness to just destroy people's lives and livelihoods, they will have accomplished their task. That's wrong. It's cynical. And we shouldn't be a part of it."
https://www.alternet...led-prediction/
They are two sisters in two states. Both are dedicated health care professionals who watched in horror as COVID-19 swept through the nation’s nursing homes, killing a staggering number of residents and staff alike.
One sister is now vaccinated. The other is not.
“Dude. Get vaccinated!” Heidi Lucas texted her sister Ashley in May from her home in Jefferson City, Missouri.
“Nope lol,” Ashley Lucas texted back from Orbisonia, Pennsylvania.
“Don’t you work with old people?”
“Yeah”
“What if you killed one of them? Get vaccinated,” Heidi wrote.
Neither sister is budging as the Delta variant brings a new spike in coronavirus numbers across the nation.
Their divide mirrors America’s larger one, where the vaccine to combat COVID-19 is eagerly embraced by some, yet eyed with suspicion and rejected by others.
It is the refusal group, including a significant percentage who work in the nation’s nursing homes, that has confounded and alarmed health care officials who are at a loss as to how to sway them.
Nursing homes faced a shocking mortality rate during the pandemic. In the U.S., COVID-19 killed more than 133,000 residents and nearly 2,000 staff members between May 31, 2020 and this July 4, according to Centers for Medicare & Medicaid Services reports. The true toll is thought to be even higher as data gathering lagged in the early months of the crisis, health experts say.
Working in a nursing home became one of the “most dangerous jobs” in America in 2020, according to an analysis of work-related deaths by Scientific American.
long & thorough as always
https://www.propubli...ovid-19-vaccine
we are nowhere near the end of this pandemic
美国单日新增新冠肺炎病例超5万例 死亡人数超61万
There are more than 50,000 new cases of COVID-19 in the United States in a single day, and the death toll exceeds 610,000
http://www.chinanews...3/9526948.shtml
(Jul 16) LONDON -- The U.K. recorded more than 50,000 new coronavirus cases in one day Friday for the first time in six months, as the British government's top medical adviser warned that the number of people hospitalized with COVID-19 could hit “quite scary” levels within weeks.
https://www.ctvnews....eased-1.5511517
remember this major milestone july 2, 2020: U.S. sees 50,000 new cases of COVID-19 reported in a single day, setting record
https://www.ctvnews....ecord-1.5007676
we aren't really any better off now than a year ago
(Bloomberg) -- The pandemic has a new epicenter, with Indonesia taking the lead in the dismal Covid-19 stakes after a recent streak of 50,000 infections a day.
The surge in the world’s fourth-most populous country is being accompanied by what are now tragically familiar stories. Hospitals are short of life-saving oxygen and drugs, and people are dying alone, their loved ones absent or behind protective screens. Indonesia is seeing more than 1,000 virus fatalities every day.
Across the world in the U.K., however, 50,000 cases has an entirely different impact. The nation eased a raft of pandemic restrictions on July 19, dubbed “Freedom Day” by the local press. Revelers jammed nightclubs for the first time in months, commuters can ride the train mask-free and diners are eating out without seating and capacity limits. Despite the jump in infections, around 50 people are dying each day.
The key difference? Vaccination. More than half the population in the U.K. -- 55% -- is fully inoculated against Covid, including most of its elderly and those at high risk, providing protection from serious disease and hospitalization.
In Indonesia, just 6% of people are fully immunized. Shots are scarce and the population is scared and vulnerable, unable to fend off a pathogen that has stalked the world since late 2019.
As richer nations turn back the clock, holding film festivals, fashion weeks and football championships once again, the worst health crisis in a generation continues to sweep the developing world, shuttering economies and dashing livelihoods. It’s the manifestation of what the World Health Organization warned about months ago: a “catastrophic moral failure” from the rich-poor divide in vaccine access. The lack of protection in emerging economies like Indonesia and, earlier, India and parts of Latin America, is not only deadly for individuals and devastating for local communities, it’s imperiling the world.
“It’s a toxic cocktail for disaster, and it’s going to be very hard to avoid,” said Joanne Liu, professor of global health at McGill University in Montreal and the former international president of Doctors Without Borders. “It’s like climate change. We see it coming, we don’t know how we’re going to stop it -- it needs a huge collective effort.”
https://www.bnnbloom...ffers-1.1632014
Edited by amor de cosmos, 23 July 2021 - 12:41 PM.