With gas up over two bucks a gallon, driving around shopping may not be the most thrifty procedure for purchasing whatever it is you're looking for.
As well, lots of store shelves are still very often "out of stock" in this post COVID world.
As well, there are always folks who don't view live shopping trips as anything but a grinding chore, far removed from something to be engaged in for pleasure.
But the short answer to your question is simply "anything at all".
Went to the grocery store yesterday. Dropped around $100, almost all of that fresh food - meat, fruit and veg, dairy. The only item I bought you could get on Amazon was tea. I looked that tea up on Amazon last night. Either the same price or much more than I paid at the store.