Like, could you not fill a 100 passenger plane three times weekly with people from metro NYC (26 million people) who want to experience Vancouver Island? Pair it with a boutique cruise operation and line up flights from NYC, LA, Houston and MIA. Can it not be done?
No. 50 passenger planes didn't work between San Fransisco and Victoria, and that's with the benefit of a significant connecting hub there.
Going three times as far means burning a lot more fuel.
And there isn't really an aircraft that fits 100 passengers that would have the legs for such a route. A220 is in the 140 passenger range. The E195 is in the 130 passenger range.
Any of the point to point demand can pass over Vancouver, Seattle, Calgary, Montreal or Toronto.
If you're talking cruise you need significantly more demand than a handful of aircraft can provide. And that's extremely seasonal.